Synthesis of Azacarbolines via PhIO

Authors :: Matteo, Corrieri
Lucia, De Crescentini
Fabio, Mantellini
Giacomo, Mari
Stefania, Santeusanio
Gianfranco, Favi
Source :: The Journal of Organic Chemistry
Publication Year :: 2021
Abstract: An unprecedented synthesis of polysubstituted indole-fused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO2) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.