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Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease
- Source :
- PLoS ONE
- Publication Year :
- 2017
-
Abstract
- Patients with chronic kidney disease (CKD) have an increased risk of infection and poorer responses to vaccination. This suggests that CKD patients have an impaired responsiveness to all antigens, even those first encountered before CKD onset. To examine this we evaluated antibody responses against two childhood vaccine antigens, tetanus (TT) and diphtheria toxoids (DT) and two common pathogens, cytomegalovirus (CMV) and Salmonella enterica serovar Enteritidis (SEn) in two independent cohorts consisting of age-matched individuals with and without CKD. Sera were evaluated for antigen-specific IgG titres and the functionality of antibody to SEn was assessed in a serum bactericidal assay. Surprisingly, patients with CKD and control subjects had comparable levels of IgG against TT and DT, suggesting preserved humoral memory responses to antigens encountered early in life. Lipopolysaccharide-specific IgG titres and serum bactericidal activity in patients with CKD were also not inferior to controls. CMV-specific IgG titres in seropositive CKD patients were similar or even increased compared to controls. Therefore, whilst responses to new vaccines in CKD are typically lower than expected, antibody responses to antigens commonly encountered prior to CKD onset are not. The immunodeficiency of CKD is likely characterised by failure to respond to new antigenic challenges and efforts to improve patient outcomes should be focussed here.
- Subjects :
- Male
Infectious Disease Control
Physiology
Humoral Immune Response
Immunology
Antibody Response
urologic and male genital diseases
Infections
Research and Analysis Methods
Biochemistry
Antibodies
Immune Physiology
Chronic Kidney Disease
Medicine and Health Sciences
Humans
Public and Occupational Health
Antigens
Renal Insufficiency, Chronic
Enzyme-Linked Immunoassays
Immunoassays
Immune Response
Aged
Vaccines
Immune System Proteins
Immunity
Biology and Life Sciences
Proteins
Middle Aged
Antibodies, Bacterial
Vaccination and Immunization
female genital diseases and pregnancy complications
Immunity, Humoral
Infectious Diseases
Nephrology
Immunoglobulin G
Host-Pathogen Interactions
Humoral Immunity
Immunologic Techniques
Female
Preventive Medicine
Immunologic Memory
Biomarkers
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.pmid..........c30050a4e19d59b0ea73a3d943877323