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Potential Biochemical Pesticide-Synthesis of Neofuranocoumarin and Inhibition the Proliferation of
- Source :
- Toxins. 14(10)
- Publication Year :
- 2022
-
Abstract
- Furanocoumarins, the secondary metabolites of plants, are considered to be natural insecticides and fungicides because they prevent the invasion of plant pathogenic microorganisms and the predation of herbivorous insects. In this study, novel 2-arylfuranocoumarin derivatives were designed to synthesize by condensation, esterification, bromination, and Wittig reaction. The results showed an excellent photosensitive activity of 2-thiophenylfuranocoumarin (I34). Cell Counting Kit-8 detected that I34 could inhibit the proliferation of
- Subjects :
- Membrane Potential, Mitochondrial
Insecticides
Caspase 3
Cytochromes c
Apoptosis
Spodoptera
Poly(ADP-ribose) Polymerase Inhibitors
Caspase 9
Fungicides, Industrial
Mitochondria
Furocoumarins
Animals
Pesticides
Tumor Suppressor Protein p53
Reactive Oxygen Species
Proto-Oncogene Proteins c-akt
Cell Proliferation
Subjects
Details
- ISSN :
- 20726651
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.pmid..........c3a0e5f8f34f72afea30c24cab4e4e69