1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in

Authors :: Lutete Peguy, Khonde
Rudolf, Müller
Grant A, Boyle
Virsinha, Reddy
Aloysius T, Nchinda
Charles J, Eyermann
Stephen, Fienberg
Vinayak, Singh
Alissa, Myrick
Efrem, Abay
Mathew, Njoroge
Nina, Lawrence
Qin, Su
Timothy G, Myers
Helena I M, Boshoff
Clifton E, Barry
Frederick A, Sirgel
Paul D, van Helden
Lisa M, Massoudi
Gregory T, Robertson
Anne J, Lenaerts
Gregory S, Basarab
Sandeep R, Ghorpade
Kelly, Chibale
Source :: Journal of medicinal chemistry. 64(17)
Publication Year :: 2021
Abstract: Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against

Subjects :: Models, Molecular
Structure-Activity Relationship
Sulfonamides
Molecular Structure
Cell Wall
Drug Discovery
Antitubercular Agents
Humans
Hep G2 Cells
Microbial Sensitivity Tests
Mycobacterium tuberculosis

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