Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1

Authors :: Frank W, Lewis
Kathleen, Bird
Jean-Philippe, Navarro
Rawa, El Fallah
Jeremy, Brandel
Véronique, Hubscher-Bruder
Andrew, Tsatsanis
James A, Duce
David, Tétard
Samuel, Bourne
Mahmoud, Maina
Ilse S, Pienaar
Source :: Dalton transactions (Cambridge, England : 2003). 51(9)
Publication Year :: 2022
Abstract: Iron dysregulation, dopamine depletion, cellular oxidative stress and α-synuclein protein mis-folding are key neuronal pathological features seen in the progression of Parkinson's disease. Iron chelators endowed with one or more therapeutic modes of action have long been suggested as disease modifying therapies for its treatment. In this study, novel 1-hydroxypyrazin-2(1

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