Polyfunctional antigen specific CD4± T cell responses in Patients with HIV/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

Authors :: Maura, Manion
Afroditi, Boulougoura
Nuha, Naqvi
Silvia Lucena, Lage
Elizabeth, Richards
Christopher, Grivas
Elizabeth, Laidlaw
Safia, Kuriakose
Ana M, Ortega-Villa
Saber, Tadros
Gregg, Roby
Adam, Rupert
France, Galindo
Megan, Anderson
Alice, Pau
George, Deepe
Virginia, Sheikh
Irini, Sereti
Source :: Clin Infect Dis
Publication Year :: 2022
Abstract: In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.

ISSN :: 15376591
Database :: OpenAIRE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Accession number :: edsair.pmid..........cbe4e1a401fdae9345d9a1f2dd4d4505

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