Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na

Authors :: Meena V, Patel
Hillary M, Peltier
Mark A, Matulenko
John R, Koenig
Marc J, C Scanio
Rebecca J, Gum
Odile F, El-Kouhen
Meagan M, Fricano
Greta L, Lundgaard
Torben, Neelands
Xu-Feng, Zhang
Cenchen, Zhan
Madhavi, Pai
Nayereh, Ghoreishi-Haack
Thomas, Hudzik
Gary, Gintant
Ruth, Martin
Steve, McGaraughty
Jun, Xu
Daniel, Bow
John C, Kalvass
Philip R, Kym
David A, DeGoey
Michael E, Kort
Source :: Bioorganicmedicinal chemistry. 63
Publication Year :: 2021
Abstract: The voltage-gated sodium channel Na

Subjects :: Structure-Activity Relationship
Humans
Pain
Pain Management
Protein Isoforms
Sodium Channels

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