[Prognostic significance of p53, HER-2/neu, Ki-67 and VEGF expression in chondrosarcomas]

Authors :: E V, Stepanova
T K, Kharatishvili
M R, Lichinitser
A Iu, Baryshnikov
Iu N, Solov'ev
N N, Trapeznikov
Source :: Arkhiv patologii. 64(6)
Publication Year :: 2003
Abstract: Expression of the mutant protein-suppressor of tumor growth p53 and the receptor of epidermal growth factor of type II--HER-2/neu may serve as prognostic factors for patients with chondrosarcoma of malignancy grade II. Combined expression of these proteins in the tumor tissue correlates with shorter 5-year survival of recurrence-free patients. The data obtained may be used for prognosis of chondrosarcoma course and choice of adequate therapy.

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