Prospective clinical and DaT-SPECT imaging in premotor

To assess the value of baseline clinical and imaging biomarkers in a cohort of asymptomaticThirty-two asymptomatic carriers ofThree carriers, asymptomatic at baseline, had converted to PD at 4-year evaluation. Twenty-three participants were fully evaluated. PD converters had lower striatal DaT binding at baseline than nonconverters (Semiquantitative DaT-SPECT could be used to predict early conversion to PD in asymptomatic carriers of the