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CTLA-4 regulates tolerance induction and T cell differentiation in vivo
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 160(8)
- Publication Year :
- 1998
-
Abstract
- Cytotoxic T lymphocyte Ag-4 (CTLA-4; CD152) is an important T cell regulatory molecule. In vitro experiments have shown that the blockade of signals through CTLA-4 augments T cell expansion, while CTLA-4 cross-linking results in decreased T cell proliferation due to decreased IL-2 production. However, less is known about the role of CTLA-4 in regulating an ongoing immune response. In this study, we examined the role of CTLA-4 in the expansion, decline, tolerization, and differentiation of T cells following treatment with staphylococcal enterotoxin B (SEB). Anti-CTLA-4 treatment resulted in increased numbers of SEB-reactive T cells and blockade of subsequent tolerance induction. Further examination of the SEB-reactive cells from anti-CTLA-4-treated mice demonstrated that both the CD4+ and CD8+ Vbeta8+ T cells produced IL-4, providing evidence that not only do signals through CTLA-4 regulate T cell-tolerizing events, but they also play an important role in the differentiation of T cells in vivo.
- Subjects :
- CD4-Positive T-Lymphocytes
Mice, Inbred BALB C
Immunoconjugates
T-Lymphocytes
Cell Differentiation
CD8-Positive T-Lymphocytes
Lymphocyte Activation
Antigens, Differentiation
Abatacept
Enterotoxins
Interferon-gamma
Mice
Antigens, CD
T-Lymphocyte Subsets
Immune Tolerance
Animals
CTLA-4 Antigen
Female
Interleukin-4
Cell Division
Signal Transduction
Subjects
Details
- ISSN :
- 00221767
- Volume :
- 160
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.pmid..........d769d72d0c4d816f31b5ad850288955f