Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex

Authors :: Mary E, Matyskiela
Thomas, Clayton
Xinde, Zheng
Christopher, Mayne
Eileen, Tran
Aaron, Carpenter
Barbra, Pagarigan
Joseph, McDonald
Mark, Rolfe
Lawrence G, Hamann
Gang, Lu
Philip P, Chamberlain
Source :: Nature structuralmolecular biology. 27(4)
Publication Year :: 2019
Abstract: Thalidomide-dependent degradation of the embryonic transcription factor SALL4 by the CRL4

Subjects :: DNA-Binding Proteins
Protein Conformation
Multiprotein Complexes
Ubiquitin-Protein Ligases
Proteolysis
Ubiquitination
Humans
Crystallography, X-Ray
Adaptor Proteins, Signal Transducing
Protein Binding
Substrate Specificity
Thalidomide
Transcription Factors

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