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Autocrine Adenosine Regulates Tumor Polyfunctional CD73
- Source :
- Cancer research. 78(13)
- Publication Year :
- 2017
-
Abstract
- The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effector CD4
- Subjects :
- Ovarian Neoplasms
Adenosine
Apyrase
Interleukin-17
Breast Neoplasms
T-Lymphocytes, Helper-Inducer
GPI-Linked Proteins
T-Lymphocytes, Regulatory
Antineoplastic Agents, Immunological
Lymphocytes, Tumor-Infiltrating
Costimulatory and Inhibitory T-Cell Receptors
Drug Resistance, Neoplasm
Humans
Female
Tumor Escape
5'-Nucleotidase
Subjects
Details
- ISSN :
- 15387445
- Volume :
- 78
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancer research
- Accession number :
- edsair.pmid..........dee14d03c2a564df23177cfa310cf2d3