NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2

Authors :: Bruna Alves, Fenerich
Jaqueline Cristina, Fernandes
Ana Paula Nunes, Rodrigues Alves
Juan Luiz, Coelho-Silva
Renata, Scopim-Ribeiro
Priscila Santos, Scheucher
Christopher A, Eide
Cristina E, Tognon
Brian J, Druker
Eduardo Magalhães, Rego
João Agostinho, Machado-Neto
Fabiola, Traina
Source :: Signal transduction and targeted therapy. 5(1)
Publication Year :: 2019
Abstract: Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms (MPN); in this pathway, IRS2 is involved in the malignant transformation induced by JAK2

Subjects :: STAT3 Transcription Factor
Sulfonamides
Myeloproliferative Disorders
Cell Survival
Apoptosis
Cell Cycle Checkpoints
Janus Kinase 2
Pyrogallol
Gene Expression Regulation, Neoplastic
Cell Line, Tumor
Insulin Receptor Substrate Proteins
STAT5 Transcription Factor
Humans
Polycythemia Vera
Cell Proliferation

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