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Neurocognitive function in patients with atrial fibrillation undergoing pulmonary vein isolation

Authors :
Leon, Zwimpfer
Stefanie, Aeschbacher
Philipp, Krisai
Michael, Coslovsky
Anne, Springer
Rebecca E, Paladini
Marc, Girod
Janik, Hufschmid
Sven, Knecht
Patrick, Badertscher
Jürg H, Beer
Leo H, Bonati
Christine S, Zuern
Laurent, Roten
Tobias, Reichlin
Christian, Sticherling
David, Conen
Stefan, Osswald
Michael, Kühne
Source :
Frontiers in cardiovascular medicine. 9
Publication Year :
2022

Abstract

Atrial fibrillation (AF) is associated with cognitive dysfunction. However, neurocognitive function in AF patients undergoing pulmonary vein isolation (PVI) has not been well studied. The aim of this analysis is to compare neurocognitive function in patients who did or did not undergo PVI.We used data from the Swiss Atrial Fibrillation Cohort study (Swiss-AF), a prospective, observational, multicenter study in Switzerland. Patients with documented AF were enrolled and data of 1,576 patients without history of PVI and with complete information on PVI status and neurocognitive function were used. Information on PVI was collected at baseline and during 1 year of follow-up. Neurocognitive testing was performed at baseline and after 1 year of follow-up, using the Montreal Cognitive Assessment (MoCA), trail making test (TMT) A and B, digit symbol substitution test (DSST) and semantic fluency test (SFT). To investigate the association of PVI with neurocognitive function, we use propensity score matching (1:3) and inverse probability of treatment weighting (IPTW).The mean age of this population was 74 ± 8 years, 27.1% were women. Overall, 88 (5.5%) patients underwent PVI during 1 year of follow-up. Using ITPW (In this population of AF patients, there was no consistent evidence of an association between PVI and neurocognitive function.[https://clinicaltrials.gov/], identifier [NCT02105844].

Details

ISSN :
2297055X
Volume :
9
Database :
OpenAIRE
Journal :
Frontiers in cardiovascular medicine
Accession number :
edsair.pmid..........e5284e5535781dfacb31ba49008e50b4