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Authors :: Narsimha Reddy, Penthala
Venumadhav, Janganati
Terri L, Alpe
Scott M, Apana
Marc S, Berridge
Peter A, Crooks
Michael J, Borrelli
Source :: Bioorganicmedicinal chemistry letters. 26(24)
Publication Year :: 2016
Abstract: The aim of this study was to determine the uptake of intravenously administered N-[11CH3]dimethylaminoparthenolide (DMAPT) into orthotopic 9LSF glioblastoma brain tumors in Fisher 344 rats from positron emission tomography (PET) imaging studies. [11C]Methyl iodide (11CH3I) was utilized as a [11C]-labeling reagent to label the precursor methylaminoparthenolide (MAPT) intermediate. From PET imaging studies it was found that brain uptake of N-[11CH3]DMAPT into brain tumor tissue was rapid (30 minutes), and considerably higher than that in the normal brain tissue.