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Clinicopathologic significance of Her-2 and P
- Source :
- Asian journal of surgery. 46(1)
- Publication Year :
- 2022
-
Abstract
- To detect the expression of HER-2 and P53 patients with gastric cancer and to analyze their correlation.A total of 249 gastric cancer patients with complete clinical data who received surgical treatment from China-Japan Union Hospital of Jilin University were selected. The expression of Her-2 and P53 were detected by immunohistochemistry using the streptavidin-biotin-peroxidase method. The correlations between HER-2 and P53 in gastric cancer were analyzed.The positive rate of Her-2 and P53 expression was 37.3% (93/249) and 100% in all the specimens, respectively. The intensity of Her-2 expression was significantly different in patients with different degrees of gastric cancer cell differentiation (P = 0.012). Meanwhile, the expression of her-2 was closely related to whether the pathological type of gastric cancer was a signet-ring cell carcinoma (P = 0.022). Different percentage of positive P53 expression was closely related to the grade of tumor differentiation (P = 0.035) and positive Ki67 expression (P = 0.001). There was a significant positive correlation between HER-2 and P53 expression in gastric cancer (P = 0.003). These findings suggest that HER-2 and P53 have synergistic effects in gastric cancer.Her-2 and P53 are important markers for invasion and metastasis of gastric cancer. Combined detection of P53 and Her-2 expression in gastric cancer tissue can be used to assess prognosis and screen cancer patients at high risk of metastasis.
Details
- ISSN :
- 02193108
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Asian journal of surgery
- Accession number :
- edsair.pmid..........e6627b7e5b9989cc2c9a4d67aa705bc9