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Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine

Authors :
Qihao, Wu
Bailey A, Bell
Jia-Xuan, Yan
Marc G, Chevrette
Nathan J, Brittin
Yanlong, Zhu
Shaurya, Chanana
Mitasree, Maity
Doug R, Braun
Amelia M, Wheaton
Ilia A, Guzei
Ying, Ge
Scott R, Rajski
Michael G, Thomas
Tim S, Bugni
Source :
Journal of the American Chemical Society.
Publication Year :
2022

Abstract

Although microbial genomes harbor an abundance of biosynthetic gene clusters, there remain substantial technological gaps that impair the direct correlation of newly discovered gene clusters and their corresponding secondary metabolite products. As an example of one approach designed to minimize or bridge such gaps, we employed hierarchical clustering analysis and principal component analysis (

Details

ISSN :
15205126
Database :
OpenAIRE
Journal :
Journal of the American Chemical Society
Accession number :
edsair.pmid..........e79cd6b6ac57146f3521621b1642dabe