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Low-Frequency Electrical Stimulation Reduces the Impairment in Synaptic Plasticity Following Epileptiform Activity in Rat Hippocampal Slices through α
- Source :
- Neuroscience. 406
- Publication Year :
- 2018
-
Abstract
- Low frequency stimulation (LFS) has anticonvulsant effect and may restore the ability of long-term potentiation (LTP) to the epileptic brain. The mechanisms of LFS have not been completely determined. Here, we showed that LTP induction was impaired following in vitro epileptiform activity (EA) in hippocampal slices, but application of LFS prevented this impairment. Then, we investigated the involvement of α-adrenergic receptors in this effect of LFS. EA was induced by increasing the extracellular K
- Subjects :
- Male
Neuronal Plasticity
Long-Term Potentiation
Adrenergic alpha-2 Receptor Antagonists
Hippocampus
Synaptic Transmission
Electric Stimulation
Rats
Organ Culture Techniques
Receptors, Adrenergic, alpha-2
Seizures
Receptors, Adrenergic, alpha-1
Synapses
Adrenergic alpha-1 Receptor Antagonists
Animals
Rats, Wistar
Subjects
Details
- ISSN :
- 18737544
- Volume :
- 406
- Database :
- OpenAIRE
- Journal :
- Neuroscience
- Accession number :
- edsair.pmid..........e89c04010b9adb7458f53ced611c19af