Association of

Thrombospondin-1 (THBS1) derived from platelets and acted as a critical mediator of hemostasis promoting platelet activation in thrombus formation. The biological connection of genetic variants and mRNA expression ofTo evaluate the association of single nucleotide polymorphisms (SNPs) and mRNA expression ofA case-control study consisted of 4,584 IS patients recruited from five hospitals in Jiangsu, China, and 4,663 age-gender-matched controls free of IS. A cohort study enrolled 4,098 participants free of stroke and lasted from 2009 to 2022. Early collected 3158 IS patients aged between 35 and 80 years were followed up an average of 5.86-year to follow up their long-term death outcomes. Two tagSNPs of theThere is no significant difference in genotype and haplotype frequencies of rs2236741 and rs3743125 between IS cases and controls (allTherefore, our study suggested that there is no significant association of