Evaluation of

Extended-spectrum -lactamases (ESBLs) mechanism of resistance in Enterobacterales leads to poor clinical outcomes. Ceftazidime/avibactam and ceftolozane/tazobactam are two broad-spectrum antimicrobial combinations that are effective against multidrug-resistant organisms with regional variations. This study aims to evaluate the antimicrobial susceptibility test (AST) for both combinations against ESBL-producing Enterobacterales isolated from intensive care units (ICUs) in tertiary hospitals from November 2012 to October 2013 in Qatar.A total of 629 Enterobacterales isolates from ICUs were screened for ESBL production using BD-PhoenixThe prevalence of ESBL-producing Enterobacterales isolated from ICUs was 17.3% (109/629) with predominance ofESBL-producing Enterobacterales isolated from ICUs were predominantly