Inotropic effects of 1-alpha-acetylmethadol (LAAM)

Inotropic effects of 1-alpha-acetylmethadol, 1-alpha-acetylnormethadol and 1-alpha-acetyldinormethadol were studied uilizing isolated left atria of guinea pigs. All three agents produced a biphasic response. Lower concentrations produced a slight, but significant increase in contractile force (p less than 0.05) and higher concentrations decreased contractile force (p less than 0.05). Significant drug interactions also were observe. The parent compound, 1-alpha-acetylmethadol, decrease the maximum positive inotropic response obtained with ouabain as well as that obtained with norepinephrine.