[Expert consensus on diagnosis and treatment of latent tuberculosis infection in patients with rheumatic diseases]

Rheumatic diseases, a typical kind of autoimmune disease, are often treated with glucocorticoids, immunosuppressants, biological agents, and small-molecule targeted drugs, which often leads to immune dysfunction in patients and increases the risk of activation of latent tuberculosis infection. To regulate the screening, diagnosis, and prophylactic treatment of latent tuberculosis infection in patients with rheumatic diseases, reduce the risk of developing active tuberculosis and improve the prognosis, Peking University Shenzhen Hospital, Shenzhen Third People's Hospital and Peking Union Medical College Hospital jointly organized domestic experts in the field of rheumatology and tuberculosis to establish the expert consensus on the diagnosis and treatment of latent tuberculosis infection in patients with rheumatic diseases. This consensus focuses on epidemiology, the importance of screening, screening methods, and prophylactic anti-tuberculosis treatment strategies for latent tuberculosis infection combined with rheumatic diseases.风湿性疾病作为一类常见的自身免疫病，治疗上经常使用糖皮质激素、免疫抑制剂、生物制剂和小分子靶向药物等，其应用往往会导致患者自身免疫功能异常，增加潜伏结核被激活的风险。为进一步规范风湿性疾病患者结核分枝杆菌潜伏感染的筛查、诊断和预防性治疗等问题，共识组组织国内结核病和风湿病领域的专家制定了本共识，重点阐述了风湿性疾病合并结核分枝杆菌潜伏感染的流行病学、筛查的重要性、筛查方法和预防性抗结核治疗策略等，旨在降低风湿性疾病合并结核分枝杆菌潜伏感染者进展为活动性结核的风险，改善患者预后。.