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Treatment of Recurrent Hepatitis C Genotype-4 Post-Liver Transplantation with Sofosbuvir plus Simeprevir
- Source :
- International Journal of Organ Transplantation Medicine
- Publication Year :
- 2015
- Publisher :
- Avicenna Organ Transplantation Institute, 2015.
-
Abstract
- Hepatitis C virus (HCV) infection remains a leading indication for orthotopic liver transplantation (OLT) worldwide. Recurrence of HCV following OLT is universal. There is scarcity of data on the post-OLT treatment of HCV genotype-4—the predominant genotype in North Africa and the Middle East. Herein, we present three patients who have experienced HCV genotype-4 recurrence post-OLT. All three patients were interferon-naive and were treated with simeprivir (SIM) and sofosbuvir (SOF) combination therapy for 12–24 weeks. The data from this case series show that SIM+SOF are well-tolerated and effective for achieving viral clearance in HCV genotype-4 post-OLT patients. Given the limited nature of a case series, further research must be pursued regarding post-OLT HCV genotype-4 responses to direct-acting anti-viral therapy.
Details
- Language :
- English
- ISSN :
- 20086490 and 20086482
- Volume :
- 6
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International Journal of Organ Transplantation Medicine
- Accession number :
- edsair.pmid..........f0c3b19029ba0a1ce4df42dce5511b92