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[The study of the expression and the prognostic value of Survivin and Ki67 in pancreatic endocrine tumors]

Authors :
Wang-wang, Liu
Yi, Zheng
Zuo-li, Xia
Shi-qiang, Zhang
Fang, Bao
Zhong-min, Lin
Xiu-huan, Ji
Li-li, Ying
Ling-ling, Zhao
Meng-fei, Xu
Cai Guo-Ping
Guo-rong, Chen
Source :
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 31(1)
Publication Year :
2015

Abstract

To explore the relationship between the expression of Survivin and Ki67 with prognosis of pancreatic endocrine tumors (PETs).Immunohistochemistry for Survivin and Ki67 was performed in 25 cases of normal pancreatic tissues and 81 cases of PETs by tissue microarrays and to observe the expression and evaluate the relationship with prognosis.(1)The expression of Survivin and Ki67 in PETs was significantly higher than that in normal pancreatic tissues (P0.01); (2)The expression of Survivin and Ki67 in PETs was correlated with tissue grading and the TNM-staging (P0.05), but not related with tumor size, location and functional status. In addition, the expression of nuclear Survivin was association with lymph node metastasis (P0.05). (3)The high expression of Ki67 was related with the expression of nuclear Survivin, but not related with the expression of cytoplasmic Survivin.Survivin and Ki67 were both expressed in PETs, which were closely related to the clinical pathological characteristics. They could be used as new indicators in the evaluation of prognosis of PETs. The expression of Survivin in nucleus had more diagnostic significance than that in cytoplasm, and that could be highly correlated with lymph node metastasis, which would be used as a new marker of poor prognosis.

Details

ISSN :
10006834
Volume :
31
Issue :
1
Database :
OpenAIRE
Journal :
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Accession number :
edsair.pmid..........f675a273df87b36983ffa95dfe8cd9ec