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Obstruction of BRAF

Authors :
J H, Rothman
O, Surriga
E, de Stanchina
S D, Vasudeva
G K, Schwartz
Source :
Cancer gene therapy. 24(9)
Publication Year :
2017

Abstract

Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand invasion and effectively obstruct transcription. Irreversibly obstructing the transcription or replication of a gene sequence, such as BRAF

Subjects

Subjects :
Peptide Nucleic Acids
Proto-Oncogene Proteins B-raf
Mice
Amino Acid Substitution
Transcription, Genetic
Mutation, Missense
Animals
Humans
Mice, Nude
Female
Melanoma
Xenograft Model Antitumor Assays

Details

ISSN :
14765500
Volume :
24
Issue :
9
Database :
OpenAIRE
Journal :
Cancer gene therapy
Accession number :
edsair.pmid..........fb1903a16d6a92edc53890d358e682b0

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Authors Abstract Subjects Details