MG53, A Novel Regulator of KChIP2 and I

Authors :: Wenjuan, Liu
Gang, Wang
Cuicui, Zhang
Wenwen, Ding
Wanwen, Cheng
Yizhi, Luo
Chaoliang, Wei
Jie, Liu
Source :: Circulation. 139(18)
Publication Year :: 2019
Abstract: KChIP2 (KMG53 expression is manipulated by genetic ablation of MG53 in mice and adenoviral overexpression or knockdown of MG53 by RNA interference in cultured neonatal rat ventricular myocytes. Cardiomyocyte hypertrophy is produced by phenylephrine stimulation in neonatal rat ventricular myocytes, and pressure overload-induced mouse cardiac hypertrophy is produced by transverse aortic constriction.KChIP2 expression and IThese findings establish MG53 as a novel regulator of KChIP2 and I