Activation of protein kinase C inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages

Background and Aims: Platelet activating factor (PAF), a potent phospholipid mediator, has been implicated in a number of reproductive processes through ovulation to parturition. To clarify the regulatory mechanism of PAF metabolism in the decidua, we have investigated the effect of activation of protein kinase C (PKC) on the secretion of PAF‐acetylhydrolase (PAF‐AH), a PAF‐inactivating enzyme, by human decidual macrophages.