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The Effect of Intrathecal Administration of Muscimol on Modulation of Neuropathic Pain Symptoms Resulting from Spinal Cord Injury; an Experimental Study

Authors :
Hosseini, Marjan
Karami, Zohreh
Janzadenh, Atousa
Jameie, Seyed Behnamedin
Haji Mashhadi, Zahra
Yousefifard, Mahmoud
Nasirinezhad, Farinaz
Source :
Archives of Academic Emergency Medicine, Vol 2, Iss 4 (2018), Emergency, Vol 2, Iss 4, Pp 151-157 (2014), Emergency
Publication Year :
2018
Publisher :
Shahid Beheshti University of Medical Sciences, 2018.

Abstract

Introduction: Neuropathic pain can be very difficult to treat and it is one of the important medical challenging about pain treatments. Muscimol as a new agonist of gamma-Aminobutyric acid receptor type A (GABAA) have been introduced for pain management. Thus, the present study was performed to evaluate the pain alleviating effect of intrathecal injection of different doses of muscimol as GABAA receptor agonist in spinal cord injury (SCI) model of neuropathic pain. Methods: In the present experimental study male Wistar rats were treated by muscimol 0.01, 0.1 or 1 µg/10ul, intrathecally (i.t.) three weeks after induction of spinal cord injury using compression injury model. Neuropathic pain symptoms were assessed at before treatment, 15 minutes, one hour and three hours after muscimol administration. The time of peak effect and optimum dosage was assessed by repeated measures analysis of variance and analysis of covariance, respectively. Results: Muscimol with the dose of 0.01 µg in 15 minutes caused to improve the thermal hyperalgesia (df: 24, 5; F= 6.6; pConclusion: The finding of the present study revealed that using muscimol with doses of 0.01µg, 0.1µg, and 1 µg reduces the symptoms of neuropathic pain. Also the effect of GABAA agonist is short term and its effectiveness gradually decreases by time.

Details

Language :
English
ISSN :
26454904
Volume :
2
Issue :
4
Database :
OpenAIRE
Journal :
Archives of Academic Emergency Medicine
Accession number :
edsair.pmid.dedup....1a2bea407a33d2c4f39cac5d0771c455