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Role of IFN gamma on TNF alpha, IL-1 beta and IL-6 release during HHV-6 infection
- Source :
- ResearcherID
- Publication Year :
- 1996
-
Abstract
- The release of monokines such as Tumor Necrosis Factor a (TNF alpha), Interleukin-1 beta (IL-1 beta) and Interleukin-6 (IL-6) by activated monocytes/macrophages is an important step in the immune as well as in the inflammatory response. In this study the production of TNF alpha, IL-1 beta and IL-6 by human monocytes (HM) and peripheral blood mononuclear cells (PBMC) was evaluated after HHV-6 infection. Our results demonstrate that HHV-6 can selectively regulate monokine synthesis, in a time-dependent manner. Moreover, we observed a different response closely related to the cellular population (HM or PBMC) examined. The hypothesis we evaluated was that IFN gamma is an important factor triggering the activation of HHV-6 infected human monocytes, to release monokines.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- ResearcherID
- Accession number :
- edsair.pmid.dedup....21ca0c75e1669ae60387a4824fc5f17f