Back to Search
Start Over
Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study
- Source :
- GENES AND IMMUNITY, 100-108. Nature Publishing Group, ISSUE=2;STARTPAGE=100;ENDPAGE=108;ISSN=1466-4879;TITLE=GENES AND IMMUNITY, Genes and Immunity
- Publication Year :
- 2020
-
Abstract
- The genes regulating circulating levels of soluble gp130 (sgp130), the antagonist of the inflammatory response in atherosclerosis driven by interleukin 6, are largely unknown. Aims of the present study were to identify genetic loci associated with circulating sgp130 and to explore the potential association between variants associated with sgp130 and markers of subclinical atherosclerosis. The study is based on IMPROVE (n = 3703), a cardiovascular multicentre study designed to investigate the determinants of carotid intima media thickness, a measure of subclinical atherosclerosis. Genomic DNA was genotyped by the CardioMetaboChip and ImmunoChip. About 360,842 SNPs were tested for association with log-transformed sgp130, using linear regression adjusted for age, gender, and population stratification using PLINK v1.07. A p value of 1 × 10−5 was chosen as threshold for significance value. In an exploratory analysis, SNPs associated with sgp130 were tested for association with c-IMT measures. We identified two SNPs significantly associated with sgp130 levels and 24 showing suggestive association with sgp130 levels. One SNP (rs17688225) on chromosome 14 was positively associated with sgp130 serum levels (β = 0.03 SE = 0.007, p = 4.77 × 10−5) and inversely associated with c-IMT (c-IMTmean–max β = −0.001 SE = 0.005, p = 0.0342). Our data indicate that multiple loci regulate sgp130 levels and suggest a possible common pathway between sgp130 and c-IMT measures.
- Subjects :
- Male
Carotid Intima-Media Thickness
Polymorphism, Single Nucleotide
INTIMA-MEDIA THICKNESS
Article
Gene Frequency
Risk Factors
Cytokine Receptor gp130
Humans
Genetic Predisposition to Disease
POPULATION
Aged
Medicinsk genetik
RISK
VASCULAR EVENTS
Interleukin-6
GENOME-WIDE
Genetic Variation
SIGNAL TRANSDUCER GP130
Middle Aged
Atherosclerosis
POLYMORPHISM
Genetic Loci
INTERLEUKIN-6 RECEPTOR
SOLUBLE GP130
Cytokines
Female
Medical Genetics
4 SUBUNITS
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14664879
- Database :
- OpenAIRE
- Journal :
- GENES AND IMMUNITY, 100-108. Nature Publishing Group, ISSUE=2;STARTPAGE=100;ENDPAGE=108;ISSN=1466-4879;TITLE=GENES AND IMMUNITY, Genes and Immunity
- Accession number :
- edsair.pmid.dedup....230d4937385f16804f03c692cc53b473