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Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD

Authors :
Maddocks, Matthew
Shrikrishna, Dinesh
Vitoriano, Simone
Natanek, Samantha A
Tanner, Rebecca J
Hart, Nicholas
Kemp, Paul R
Moxham, John
Polkey, Michael I
Hopkinson, Nicholas S
Medical Research Council (MRC)
Source :
The European Respiratory Journal, Maddocks, M, Shrikrishna, D, Vitoriano, S, Natanek, S A, Tanner, R J, Hart, N, Kemp, P R, Moxham, J, Polkey, M I & Hopkinson, N S 2014, ' Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD ', European Respiratory Journal, vol. 44, no. 5, pp. 1188-1198 . https://doi.org/10.1183/09031936.00066414
Publication Year :
2014
Publisher :
European Respiratory Society, 2014.

Abstract

Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population. In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU. Mean±sd percentage intramuscular fat was higher in the patient group (6.7±3.5% versus 4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95). Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes.<br />CT-based skeletal muscle adiposity markers reflect muscle quality in COPD and help identify patients with fibre shift http://ow.ly/xolWA

Details

Language :
English
Database :
OpenAIRE
Journal :
The European Respiratory Journal, Maddocks, M, Shrikrishna, D, Vitoriano, S, Natanek, S A, Tanner, R J, Hart, N, Kemp, P R, Moxham, J, Polkey, M I & Hopkinson, N S 2014, ' Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD ', European Respiratory Journal, vol. 44, no. 5, pp. 1188-1198 . https://doi.org/10.1183/09031936.00066414
Accession number :
edsair.pmid.dedup....2b2d13d34ebd476d9b2bbd733198a8ab
Full Text :
https://doi.org/10.1183/09031936.00066414