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Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke
- Source :
- Stroke
- Publication Year :
- 2018
-
Abstract
- Supplemental Digital Content is available in the text.<br />Background and Purpose— It has been hypothesized that cerebral small vessel disease (SVD) and chronic renal impairment may be part of a multisystem small-vessel disorder, but their association may simply be as a result of shared risk factors (eg, hypertension) rather than to a systemic susceptibility to premature SVD. However, most previous studies were hospital based, most had inadequate adjustment for hypertension, many were confined to patients with lacunar stroke, and none stratified by age. Methods— In a population-based study of transient ischemic attack and ischemic stroke (OXVASC [Oxford Vascular Study]), we evaluated the magnetic resonance imaging markers of cerebral SVD, including lacunes, white matter hyperintensities, cerebral microbleeds, and enlarged perivascular space. We studied the age-specific associations of renal impairment (estimated glomerular filtration rate
- Subjects :
- Male
Original Contributions
Clinical Sciences
Humans
magnetic resonance imaging
Renal Insufficiency
Aged
Cerebral Hemorrhage
Aged, 80 and over
cerebral small vessel disease
Age Factors
Middle Aged
White Matter
stroke
Ischemic Attack, Transient
Cerebral Small Vessel Diseases
transient ischemic attack
Stroke, Lacunar
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Female
Glymphatic System
chronic kidney disease
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 00392499
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.pmid.dedup....362e388806a982c3da400e9e36bb157a
- Full Text :
- https://doi.org/10.1161/STROKEAHA.117.019650