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Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo
- Source :
- Nature Communications, Nature Communications, Nature Publishing Group, 2019, 10, pp.2098. ⟨10.1038/s41467-019-10117-z⟩, Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019), Nature Communications, 2019, 10, pp.2098. ⟨10.1038/s41467-019-10117-z⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; Hepatitis D virus (HDV) doesn't encode envelope proteins for packaging of its ribonucleo-protein (RNP) and typically relies on the surface glycoproteins (GPs) from hepatitis B virus (HBV) for virion assembly, envelopment and cellular transmission. HDV RNA genome can efficiently replicate in different tissues and species, raising the possibility that it evolved, and/ or is still able to transmit, independently of HBV. Here we show that alternative, HBV-unrelated viruses can act as helper viruses for HDV. In vitro, envelope GPs from several virus genera, including vesiculovirus, flavivirus and hepacivirus, can package HDV RNPs, allowing efficient egress of HDV particles in the extracellular milieu of co-infected cells and subsequent entry into cells expressing the relevant receptors. Furthermore, HCV can propagate HDV infection in the liver of co-infected humanized mice for several months. Further work is necessary to evaluate whether HDV is currently transmitted by HBV-unrelated viruses in humans.
- Subjects :
- Science
viruses
Primary Cell Culture
Mice, Transgenic
Hepacivirus
Mice
Viral Envelope Proteins
Mice, Inbred NOD
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Cell Line, Tumor
Animals
Humans
lcsh:Science
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Coinfection
Flavivirus
Virus Assembly
Virion
virus diseases
Vesiculovirus
biochemical phenomena, metabolism, and nutrition
Hepatitis D
digestive system diseases
Ribonucleoproteins
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Hepatocytes
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
RNA, Viral
lcsh:Q
Hepatitis Delta Virus
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nature Communications, Nature Publishing Group, 2019, 10, pp.2098. ⟨10.1038/s41467-019-10117-z⟩, Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019), Nature Communications, 2019, 10, pp.2098. ⟨10.1038/s41467-019-10117-z⟩
- Accession number :
- edsair.pmid.dedup....39d75693dd10acd00d8577a1c83fd5e8