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[Role of the Regulatory T lymphocytes in hepatitis C fibrosis progression]
- Source :
- Bulletin du Cancer, Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (11), pp.1029-38. ⟨10.1684/bdc.2008.0752⟩, Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (11), pp.1029-38. 〈10.1684/bdc.2008.0752〉
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- International audience; Hepatitis C virus (HCV) becomes chronic in about 85 % of infected individuals, whereas only 15 % of infected people clear spontaneously the virus. The progression of hepatitis C to chronic status is associated to a profound down-regulation of CD4 and CD8 multispecific immune response. This immune defect may participate to the immune tolerance of VHC and consequently to its persistence. Recent findings indicate that T regulatory cells as Tr1 play an inhibitory role on T helper responses notably in the context of auto-immune or inflammatory disorders. The existence of immunosuppressive mechanisms supported by Tr1 lymphocytes and their IL-10 production represent an attractive hypothesis. We have previously evaluated the existence of regulatory T cells (Tr1) via high production of IL-10, in liver biopsies of three well-defined cohorts of HCV-1b infected patients. To this purpose, we compared liver biopsies of chronically infected patients including patients without liver lesions, with cirrhosis and with hepatocellular carcinoma (HCC). Using quantitative real time PCR, the results obtained demonstrate, an increased expression of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta)_, in liver biopsies with more severe fibrosis. This observation was correlated with an increased expression during the pathogenesis progression, of the three specific markers of the Tr1 cells sub-population, recently described and confirming the Tr1 phenotype. Evidence of regulatory T cells installation in the liver of chronically infected patient and increased frequency in cirrhosis and HCC suggest a main role of these cells in the aggravation of the liver pathology. This study should bring insight of T regulatory cell implications in VHC persistence and in the pathology progression.
- Subjects :
- Liver Cirrhosis
MESH : Liver Neoplasms
MESH: Interleukin-10
MESH : Cytokines
Biopsy
[ SDV.TOX ] Life Sciences [q-bio]/Toxicology
MESH : Aged
MESH : T-Lymphocytes, Helper-Inducer
Hepacivirus
T-Lymphocytes, Regulatory
MESH : Hepacivirus
MESH : T-Lymphocytes, Regulatory
MESH: Biopsy
Transforming Growth Factor beta
MESH: Liver Neoplasms
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
MESH: Hepacivirus
[ SDV.IB ] Life Sciences [q-bio]/Bioengineering
MESH: Carcinoma, Hepatocellular
MESH: Antigens, CD
MESH: Aged
MESH: Cytokines
MESH: Middle Aged
MESH : Immune Tolerance
Liver Neoplasms
T-Lymphocytes, Helper-Inducer
MESH : Adult
Middle Aged
Hepatitis C
Interleukin-10
MESH: Hepatitis C, Chronic
Liver
[SDV.TOX]Life Sciences [q-bio]/Toxicology
Disease Progression
Cytokines
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH : DNA Primers
MESH: Disease Progression
[SDV.IB]Life Sciences [q-bio]/Bioengineering
MESH: Liver Cirrhosis
MESH : Carcinoma, Hepatocellular
Adult
MESH: DNA Primers
Carcinoma, Hepatocellular
MESH: Immune Tolerance
MESH : Hepatitis C, Chronic
Antigens, CD
MESH : Interleukin-10
MESH : Antigens, CD
Immune Tolerance
MESH : Liver Cirrhosis
Humans
MESH : Middle Aged
MESH: T-Lymphocytes, Helper-Inducer
MESH: Transforming Growth Factor beta
Aged
DNA Primers
MESH: Hepatitis C
MESH: Humans
MESH: T-Lymphocytes, Regulatory
MESH : Humans
MESH : Liver
MESH: Adult
MESH : Disease Progression
MESH : Hepatitis C
Hepatitis C, Chronic
MESH : Transforming Growth Factor beta
MESH : Biopsy
MESH: Liver
Subjects
Details
- Language :
- French
- ISSN :
- 00074551 and 17696917
- Database :
- OpenAIRE
- Journal :
- Bulletin du Cancer, Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (11), pp.1029-38. ⟨10.1684/bdc.2008.0752⟩, Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (11), pp.1029-38. 〈10.1684/bdc.2008.0752〉
- Accession number :
- edsair.pmid.dedup....3dd04537cb3c78bcf2ae64c48751dc03