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Effects of maternal geohelminth infections on allergy in early childhood
- Source :
- The Journal of Allergy and Clinical Immunology
- Publication Year :
- 2016
- Publisher :
- Mosby, 2016.
-
Abstract
- BACKGROUND: Maternal geohelminth infections during pregnancy may protect against allergy development in childhood. OBJECTIVE: We sought to investigate the effect of maternal geohelminths on the development of eczema, wheeze, and atopy during the first 3 years of life. METHODS: A cohort of 2404 neonates was followed to 3 years of age in a rural district in coastal Ecuador. Data on wheeze and eczema were collected by means of questionnaire and physical examination at 13, 24, and 36 months of age. Atopy was measured based on skin prick test (SPT) reactivity to 9 allergens at 36 months. Maternal stool samples were examined for geohelminths by microscopy. Data on potential confounders was collected after birth by questionnaire. RESULTS: Geohelminths were observed in 45.9% of mothers. Eczema and wheeze were reported for 17.7% and 25.9%, respectively, of 2069 (86.1%) children with complete follow-up to 3 years, and allergen SPT reactivity to any allergen was present in 17.2% and to house dust mite in 8.7%. Maternal geohelminth infections were not significantly associated with eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61), wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61-1.01). In subgroup analyses maternal geohelminths were associated with a significantly reduced risk of SPT reactivity to mite and other perennial allergens, and maternal ascariasis was associated with an increased risk of eczema and reduced risk of SPT reactivity to all allergens. CONCLUSION: Our data do not support a protective effect of maternal infections with geohelminth parasites during pregnancy against the development of eczema and wheeze in early childhood, although there was evidence in subgroup analyses for a reduction in SPT reactivity to house dust mites and perennial allergens.
- Subjects :
- Male
Immunology
atopy
Eczema
Helminthiasis
epg, Eggs per gram
immune system diseases
Immune Deficiencies, Infection, and Systemic Immune Disorders
Pregnancy
Risk Factors
parasitic diseases
otorhinolaryngologic diseases
Hypersensitivity
Odds Ratio
Immunology and Allergy
Animals
Humans
HDM, House dust mite
Geohelminths
Respiratory Sounds
Pyroglyphidae
Infant, Newborn
Infant
SPT, Skin prick test
early childhood
Allergens
Patient Outcome Assessment
maternal infections
Maternal Exposure
wheeze
Child, Preschool
Female
OR, Odds ratio
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 10976825 and 00916749
- Volume :
- 137
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.pmid.dedup....4237e589f73c32d0b2b5564e2e3d8fa4