Predicting delivery of a small‐for‐gestational‐age infant and adverse perinatal outcome in women with suspected pre‐eclampsia

Authors :: Griffin, M.
Seed, P. T.
Duckworth, S.
North, R.
Myers, J.
Mackillop, L.
Simpson, N.
Waugh, J.
Anumba, D.
Kenny, L. C.
Redman, C. W. G.
Shennan, A. H.
Chappell, L. C.
Source :: Ultrasound in Obstetrics & Gynecology
Publication Year :: 2018
Publisher :: John Wiley & Sons, Ltd., 2018.
Abstract: Objective To evaluate the test performance of 47 biomarkers and ultrasound parameters for the prediction of delivery of a small‐for‐gestational‐age (SGA) infant and adverse perinatal outcome in women presenting with suspected pre‐eclampsia. Methods This was a prospective, multicenter observational study in which 47 biomarkers and ultrasound parameters were measured in 397 women with a singleton pregnancy presenting with suspected preterm pre‐eclampsia between 20 + 0 and 36 + 6 weeks' gestation, with the objective of evaluating them as predictors of subsequent delivery of a SGA infant and adverse perinatal outcome. Women with confirmed pre‐eclampsia at enrollment were excluded. Factor analysis and stepwise logistic regression were performed in two prespecified groups stratified according to gestational age at enrollment. The primary outcome was delivery of a SGA infant with a birth weight<br />Linked Comment: Ultrasound Obstet Gynecol 2018; 51: 304–305

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