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Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice
- Source :
- Journal of Diabetes Research, Vol 2016 (2016), Journal of Diabetes Research, Journal of Diabetes Research 2016:Article ID 4536470 doi:10.1155/2016/4536470
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- The study aimed to investigate the effects of differentiated exercise regimes on high fat-induced metabolic and inflammatory pathways. Mice were fed a standard diet (ST) or a high fat diet (HFD) and subjected to regular endurance training (ET) or resistance training (RT). After 10 weeks body weight, glucose tolerance, fatty acids (FAs), circulating ceramides, cytokines, and immunological mediators were determined. The HFD induced a significant increase in body weight and a disturbed glucose tolerance (p < 0.05). An increase of plasma FA, ceramides, and inflammatory mediators in adipose tissue and serum was found (p < 0.05). Both endurance and resistance training decreased body weight (p < 0.05) and reduced serum ceramides (p < 0.005). While RT attenuated the increase of NLRP-3 (RT) expression in adipose tissue, ET was effective in reducing TNF-alpha and IL-18 expression. Furthermore, ET reduced levels of MIP-1gamma, while RT decreased levels of IL-18, MIP-1gamma, Timp-1, and CD40 in serum (p < 0.001), respectively. Although both exercise regimes improved glucose tolerance (p < 0.001), ET was more effective than RT. These results suggest that exercise improves HFD-induced complications possibly through a reduction of ceramides, the reduction of inflammasome activation in adipose tissues, and a systemic downregulation of inflammatory cytokines.
- Subjects :
- Blood Glucose
Male
Article Subject
Inflammasomes
Serine C-Palmitoyltransferase
Ceramides
Diet, High-Fat
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Glucose Intolerance
NLR Family, Pyrin Domain-Containing 3 Protein
Sphingosine N-Acyltransferase
Weight Loss
Animals
ddc:610
Obesity
Inflammation
lcsh:RC648-665
Resistance Training
Medical sciences Medicine
Mice, Inbred C57BL
Disease Models, Animal
Adipose Tissue
Liver
Physical Endurance
Cytokines
Inflammation Mediators
Carrier Proteins
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146753 and 23146745
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.pmid.dedup....4893b807c0842b3445c2282929923226