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Tumor markers in pleural effusions
- Source :
- Scopus-Elsevier, Europe PubMed Central, ResearcherID
-
Abstract
- The aim of this study was to determine the diagnostic capabilities of tumor markers in pleural effusion and their importance for assessment of the etiology of pleural effusions.In pleural effusions from 166 patients hospitalized during the period 2003-2005 at the Department of Oncology and Radiotherapy, Faculty Hospital in Pilsen, the following tumor markers were determined: thymidine kinase (TK), neuron-specific enolase (NSE), cytokeratins [tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and cytokeratin fragment 19 (CYFRA 21-1)], carcinoembryonic antigen (CEA) and mucinous markers (CA 15-3, CA 19-9, CA 125). The inflammatory marker procalcitonin-PCT was also assessed.Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%.Significant positivity of PCT and CA 15-3 in pleural effusions indicate a suspicion of inflammatory disease. Positivity of TK and CA 15-3 indicate a strong suspicion of malignant exudates.
- Subjects :
- Adult
Aged, 80 and over
Calcitonin
Keratin-19
Male
CA-19-9 Antigen
Calcitonin Gene-Related Peptide
Mucin-1
Middle Aged
Sensitivity and Specificity
Thymidine Kinase
Carcinoembryonic Antigen
Pleural Effusion
Antigens, Neoplasm
CA-125 Antigen
Neoplasms
Phosphopyruvate Hydratase
Biomarkers, Tumor
Humans
Keratins
Female
Tissue Polypeptide Antigen
Protein Precursors
Peptides
Aged
Subjects
Details
- ISSN :
- 20032005
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Europe PubMed Central, ResearcherID
- Accession number :
- edsair.pmid.dedup....4f0d3dc11691ae6c8bdb3d84615d2e90