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Impact of positional difference on the measurement of breast density using MRI
- Source :
- Chen, JH; Chan, S; Tang, YT; Hon, JS; Tseng, PC; Cheriyan, AT; et al.(2015). Impact of positional difference on the measurement of breast density using MRI. Medical Physics, 42(5), 2268-2275. doi: 10.1118/1.4917083. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0j63z7g6, Medical physics, vol 42, iss 5
- Publication Year :
- 2015
- Publisher :
- American Association of Physicists in Medicine, 2015.
-
Abstract
- © 2015 American Association of Physicists in Medicine. Purpose: This study investigated the impact of arms/hands and body position on the measurement of breast density using MRI. Methods: Noncontrast-enhanced T1-weighted images were acquired from 32 healthy women. Each subject received four MR scans using different experimental settings, including a high resolution hands-up, a low resolution hands-up, a high resolution hands-down, and finally, another high resolution hands-up after repositioning. The breast segmentation was performed using a fully automatic chest template-based method. The breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from the four MR scan settings were analyzed. Results: A high correlation of BV, FV, and PD between any pair of the four MR scans was noted (r > 0.98 for all). Using the generalized estimating equation method, a statistically significant difference in mean BV among four settings was noted (left breast, score test p = 0.0056; right breast, score test p = 0.0016), adjusted for age and body mass index. Despite differences in BV, there were no statistically significant differences in the mean PDs among the four settings (p > 0.10 for left and right breasts). Using BlandAltman plots, the smallest mean difference/bias and standard deviations for BV, FV, and PD were noted when comparing hands-up high vs low resolution when the breast positions were exactly the same. Conclusions: The authors study showed that BV, FV, and PD measurements from MRI of different positions were highly correlated.BVmay vary with positions but the measured PD did not differ significantly between positions. The study suggested that the percent density analyzed from MRI studies acquired using different arms/hands and body positions from multiple centers can be combined for analysis.
- Subjects :
- Asian Continental Ancestry Group
Adult
Aging
Image Processing
Oncology and Carcinogenesis
Posture
Biomedical Engineering
Bioengineering
Diagnostic Radiology
Body Mass Index
Cohort Studies
Young Adult
Computer-Assisted
Asian People
Clinical Research
Breast Cancer
Image Processing, Computer-Assisted
Humans
Breast
Cancer
body position
Tissue Measurements
fibroglandular tissue volume
MR
Middle Aged
Hand
breast volume
Magnetic Resonance Imaging
Other Physical Sciences
Nuclear Medicine & Medical Imaging
Arm
Biomedical Imaging
Female
percent breast density
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Chen, JH; Chan, S; Tang, YT; Hon, JS; Tseng, PC; Cheriyan, AT; et al.(2015). Impact of positional difference on the measurement of breast density using MRI. Medical Physics, 42(5), 2268-2275. doi: 10.1118/1.4917083. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0j63z7g6, Medical physics, vol 42, iss 5
- Accession number :
- edsair.pmid.dedup....4f3372b13d3e1a32f09cc0bec5dabd80