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Neurotropic virus infections as the cause of immediate and delayed neuropathology
- Source :
- Acta Neuropathologica, 131(2), 159-184, Acta Neuropathologica 131 (2016) 2, Acta Neuropathologica, Acta Neuropathologica, 131(2), 159-184. Springer-Verlag
- Publication Year :
- 2016
-
Abstract
- A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens. Electronic supplementary material The online version of this article (doi:10.1007/s00401-015-1511-3) contains supplementary material, which is available to authorized users.
- Subjects :
- Neuroinfectiology
Flavivirus
Virus infection
Picornavirus
Clinical Neurology
Herpesvirus
Review
Alphavirus
Rhabdovirus
Bornavirus
Pathology and Forensic Medicine
Virology & Molecular Biology
Virologie & Moleculaire Biologie
Cellular and Molecular Neuroscience
Paramyxovirus
Central nervous system
Central Nervous System Viral Diseases
Animals
Humans
Bunyavirus
Influenza virus
Neuropathology
Subjects
Details
- Language :
- English
- ISSN :
- 00016322
- Database :
- OpenAIRE
- Journal :
- Acta Neuropathologica, 131(2), 159-184, Acta Neuropathologica 131 (2016) 2, Acta Neuropathologica, Acta Neuropathologica, 131(2), 159-184. Springer-Verlag
- Accession number :
- edsair.pmid.dedup....560fab3ecc4325e938ee5ebce5cd6c83