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The Dilemma of HER2 Double-equivocal Breast Carcinomas
- Source :
- American Journal of Surgical Pathology, American Journal of Surgical Pathology, Lippincott, Williams & Wilkins, 2018, 42 (9), pp.1190-1200. ⟨10.1097/PAS.0000000000001100⟩, The American Journal of Surgical Pathology
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Supplemental Digital Content is available in the text.<br />The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) 2013 guidelines for HER2 assessment have increased the number of HER2 equivocal breast carcinomas following in situ hybridization reflex testing, that is, HER2 “double equivocal” (equivocal protein expression and equivocal gene copy number). Forty-five double-equivocal carcinomas were subjected to Prosigna analysis. Twenty-seven cases were investigated for the expression of genes found to be differentially expressed between estrogen receptor (ER)-positive/HER2-positive (N=22) and ER-positive/HER2-negative (N=22) control cases. Twenty-nine of the 45 cases were also analyzed by targeted sequencing using a panel of 14 genes. We then explored the pathologic complete response rates in an independent series of double-equivocal carcinoma patients treated with trastuzumab-containing chemotherapy. All cases were ER-positive, with a mean Ki67 of 28%. Double-equivocal carcinomas were predominantly luminal B (76%); 9 cases (20%) were luminal A, and 2 cases (4%) HER2-enriched. The majority (73%) showed a high risk of recurrence by Prosigna, even when the carcinomas were small (
- Subjects :
- Adult
Receptor, ErbB-2
Gene Expression Profiling
Carcinoma
Breast Neoplasms
[SDV.CAN]Life Sciences [q-bio]/Cancer
Original Articles
Middle Aged
molecular subtype
mutations
risk of recurrence
HER2
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Biomarkers, Tumor
Humans
Female
breast carcinoma
skin and connective tissue diseases
equivocal result
neoplasms
Subjects
Details
- Language :
- English
- ISSN :
- 01475185
- Database :
- OpenAIRE
- Journal :
- American Journal of Surgical Pathology, American Journal of Surgical Pathology, Lippincott, Williams & Wilkins, 2018, 42 (9), pp.1190-1200. ⟨10.1097/PAS.0000000000001100⟩, The American Journal of Surgical Pathology
- Accession number :
- edsair.pmid.dedup....5cd1d678a4f2d1fe5fb46628aee61763