Back to Search
Start Over
Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat
- Source :
- Scopus-Elsevier
-
Abstract
- BACKGROUND: Oxaliplatin neurotoxicity represents a clinically-relevant problem and its etio-pathogenesis is still unknown. We explored the possible role of some neuronal growth factors ("neurotrophins") during the course of oxaliplatin sensory neuronopathy. MATERIALS AND METHODS: In our rat model two different doses of oxaliplatin were used (2 and 3 mg/kg i.v. twice weekly for 9 times). The neurotoxicity of the treatment was assessed with neurophysiological and pathological methods and serum neurotrophin levels were measured by ELISA. RESULTS: Both oxaliplatin-treated groups showed the neurophysiological and neuropathological changes which mimic the chronic effects of oxaliplatin administration in humans, e.g. reversible sensory impairment due to dorsal root ganglia neuron damage. These changes were associated with a significant and dose-dependent reduction only in the circulating level of nerve growth factor (NGF), which returned to normal values after neurophysiological and pathological recovery. CONCLUSION: This specific association between neurological impairment and NGF modulation indicates that NGF impairment has a role in the neurotoxicity of oxaliplatin
- Subjects :
- Tail
Organoplatinum Compounds
Animal
Organoplatinum Compound
Neural Conduction
Peripheral Nervous System Diseases
Antineoplastic Agents
Sciatic Nerve
Rats
Antineoplastic Agent
Oxaliplatin
Ganglia, Spinal
Nerve Growth Factor
Rat
Animals
Female
Nerve Growth Factors
Neurons, Afferent
Peripheral Nervous System Disease
Rats, Wistar
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.pmid.dedup....627154d7b78ab7a16fb442081403b3b3