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Bone Marrow Lymphoid Niche Adaptation to Mature B Cell Neoplasms
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩, Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; B-cell non-Hodgkin lymphoma (B-NHL) evolution and treatment are complicated by a high prevalence of relapses primarily due to the ability of malignant B cells to interact with tumor-supportive lymph node (LN) and bone marrow (BM) microenvironments. In particular, progressive alterations of BM stromal cells sustain the survival, proliferation, and drug resistance of tumor B cells during diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). The current review describes how the crosstalk between BM stromal cells and lymphoma tumor cells triggers the establishment of the tumor supportive niche. DLBCL, FL, and CLL display distinct patterns of BM involvement, but in each case tumor-infiltrating stromal cells, corresponding to cancer-associated fibroblasts, exhibit specific phenotypic and functional features promoting the recruitment, adhesion, and survival of tumor cells. Tumor cell-derived extracellular vesicles have been recently proposed as playing a central role in triggering initial induction of tumor-supportive niches, notably within the BM. Finally, the disruption of the BM stroma reprogramming emerges as a promising therapeutic option in B-cell lymphomas. Targeting the crosstalk between BM stromal cells and malignant B cells, either through the inhibition of stroma-derived B-cell growth factors or through the mobilization of clonal B cells outside their supportive BM niche, should in particular be further evaluated as a way to avoid relapses by abrogating resistance niches.
- Subjects :
- B-Lymphocytes
Mini Review
[SDV]Life Sciences [q-bio]
Immunology
B-cell non-Hodgkin lymphomas
Cell Differentiation
Mesenchymal Stem Cells
Cell Communication
Leukemia, Lymphocytic, Chronic, B-Cell
Coculture Techniques
[SDV] Life Sciences [q-bio]
stroma cell
Bone Marrow
immune system diseases
hemic and lymphatic diseases
Tumor Cells, Cultured
Immunology and Allergy
Humans
tumor microenvironment
Lymphoma, Large B-Cell, Diffuse
Stem Cell Niche
extracellular vesicles
Lymphoma, Follicular
cancer-associated fibroblasts
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩, Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩
- Accession number :
- edsair.pmid.dedup....64242d509203192b875407f35ddbc64c