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Bone Marrow Lymphoid Niche Adaptation to Mature B Cell Neoplasms

Authors :
Dumontet, Erwan
Mancini, Stéphane J C
Tarte, Karin
Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC)
Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1)
Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)
CHU Pontchaillou [Rennes]
Fondation ARC [PGA1 RF20170205386]
Institut National du cancerInstitut National du Cancer (INCA) France [INCA AAP PNP19-009]
Chard-Hutchinson, Xavier
Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Université de Rennes 1 (UR1)
Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Source :
Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩, Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩
Publication Year :
2021
Publisher :
HAL CCSD, 2021.

Abstract

International audience; B-cell non-Hodgkin lymphoma (B-NHL) evolution and treatment are complicated by a high prevalence of relapses primarily due to the ability of malignant B cells to interact with tumor-supportive lymph node (LN) and bone marrow (BM) microenvironments. In particular, progressive alterations of BM stromal cells sustain the survival, proliferation, and drug resistance of tumor B cells during diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). The current review describes how the crosstalk between BM stromal cells and lymphoma tumor cells triggers the establishment of the tumor supportive niche. DLBCL, FL, and CLL display distinct patterns of BM involvement, but in each case tumor-infiltrating stromal cells, corresponding to cancer-associated fibroblasts, exhibit specific phenotypic and functional features promoting the recruitment, adhesion, and survival of tumor cells. Tumor cell-derived extracellular vesicles have been recently proposed as playing a central role in triggering initial induction of tumor-supportive niches, notably within the BM. Finally, the disruption of the BM stroma reprogramming emerges as a promising therapeutic option in B-cell lymphomas. Targeting the crosstalk between BM stromal cells and malignant B cells, either through the inhibition of stroma-derived B-cell growth factors or through the mobilization of clonal B cells outside their supportive BM niche, should in particular be further evaluated as a way to avoid relapses by abrogating resistance niches.

Details

Language :
English
ISSN :
16643224
Database :
OpenAIRE
Journal :
Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩, Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.784691⟩
Accession number :
edsair.pmid.dedup....64242d509203192b875407f35ddbc64c