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Quality of life in patients with chronic hepatitis C infection: Severe comorbidities and disease perception matter more than liver-disease stage
- Source :
- PLoS ONE, PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0215596. ⟨10.1371/journal.pone.0215596⟩, PLoS ONE, 2019, 14 (5), pp.e0215596. ⟨10.1371/journal.pone.0215596⟩, PLoS ONE, Vol 14, Iss 5, p e0215596 (2019)
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Background and aimsThis study evaluated the clinical and non-clinical determinants of health-related quality of life (HRQoL) associated with untreated chronic hepatitis C (CHC) in France.MethodsFrom 01/2014 to 01/2015, untreated CHC patients were invited to complete a questionnaire including EQ-5D utility instrument and two visual analogue scales (VAS) measuring overall health and fatigue in three French centers (Paris, Lille and Montpellier). Answers were analyzed in mixed models (taking into account the clustering effects of centers and physicians).ResultsFive hundreds and five patients were enrolled: 52% males; the mean age was 54; 41% had BMI>25; 64% had genotype 1; 36% were at the stage of severe fibrosis (F3-F4); 38% had severe comorbidities other than liver-related. In the univariate analysis, EQ-5D utility was associated with socio-demographic variables as age, place of birth, education, and employment; CHC-related variables as conditions of HCV screening and severity of fibrosis; CHC-unrelated variables as comorbidities other than CHC, being overweight, and psychiatric disorders; feelings about CHC disease as perception of progression, lack of information on CHC and its treatments, and entourage's feeling. In multivariate analysis, EQ-5D utility was affected by not being in employment (0.72 vs. 0.80), having severe comorbidities other than CHC (0.72 vs. 0.79), being overweight (0.73 vs. 0.78), and feeling worried about CHC progression (0.66 vs. 0.72-0.84). Similar results were found for the VAS.ConclusionsThe presence of severe comorbidities and worrying about CHC progression, but not stage of fibrosis, seem to alter significantly EQ-5D health utility in CHC French patients.
- Subjects :
- Male
Medical Doctors
Health Care Providers
Social Sciences
MESH: Comorbidity
Comorbidity
Pathology and Laboratory Medicine
Severity of Illness Index
Geographical locations
Families
MESH: Health Surveys
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Medicine and Health Sciences
Psychology
Public and Occupational Health
Medical Personnel
Children
Fatigue
MESH: Aged
MESH: Middle Aged
Pharmaceutics
Middle Aged
MESH: Hepatitis C, Chronic/psychology
Europe
Alcoholism
Professions
MESH: Young Adult
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Disease Progression
Medicine
Female
MESH: Disease Progression
France
Research Article
Adult
Patients
Substance-Related Disorders
Science
Addiction
Young Adult
Signs and Symptoms
MESH: Cross-Sectional Studies
Drug Therapy
Diagnostic Medicine
Physicians
MESH: Severity of Illness Index
Mental Health and Psychiatry
Humans
European Union
Aged
MESH: Humans
Biology and Life Sciences
MESH: Adult
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Hepatitis C, Chronic
Health Surveys
Fibrosis
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
MESH: Male
Health Care
MESH: France
Cross-Sectional Studies
Age Groups
People and Places
Quality of Life
MESH: Quality of Life/psychology
Population Groupings
MESH: Female
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0215596. ⟨10.1371/journal.pone.0215596⟩, PLoS ONE, 2019, 14 (5), pp.e0215596. ⟨10.1371/journal.pone.0215596⟩, PLoS ONE, Vol 14, Iss 5, p e0215596 (2019)
- Accession number :
- edsair.pmid.dedup....659ab4c97fcdd62745e213fb4e812899