Back to Search Start Over

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance

Authors :
Kirwan, D
Ugarte-Gil, C
Gilman, RH
Caviedes, L
Hasan Rizvi, SM
Ticona, E
Chavez, G
Cabrera, JL
Matos, ED
Evans, CA
Moore, DAJ
Friedland, JS
Wellcome Trust
Imperial College Healthcare NHS Trust- BRC Funding
Source :
Journal of Clinical Microbiology
Publication Year :
2015
Publisher :
American Society for Microbiology, 2015.

Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Details

Language :
English
ISSN :
1098660X and 00951137
Volume :
54
Issue :
1
Database :
OpenAIRE
Journal :
Journal of Clinical Microbiology
Accession number :
edsair.pmid.dedup....6959ac0e4ba7503893631a22df998113