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Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV
- Source :
- The Journal of Infectious Diseases, Journal of Infectious Diseases, Journal of Infectious Diseases, Oxford University Press (OUP), 2019, 219 (1), pp.89-100. ⟨10.1093/infdis/jiy495⟩, Journal of Infectious Diseases, 2019, 219 (1), pp.89-100. ⟨10.1093/infdis/jiy495⟩
- Publication Year :
- 2018
- Publisher :
- Oxford University Press, 2018.
-
Abstract
- Objective Immune activation is associated with morbidity and mortality during human immunodeficiency virus (HIV) infection, despite receipt of antiretroviral therapy (ART). We investigated whether microbial translocation drives immune activation in HIV-infected Ugandan children. Methods Nineteen markers of immune activation and inflammation were measured over 96 weeks in HIV-infected Ugandan children in the CHAPAS-3 Trial and HIV-uninfected age-matched controls. Microbial translocation was assessed using molecular techniques, including next-generation sequencing. Results Of 249 children included, 142 were infected with HIV; of these, 120 were ART naive, with a median age of 2.8 years (interquartile range [IQR], 1.7–4.0 years) and a median baseline CD4+ T-cell percentage of 20% (IQR, 14%–24%), and 22 were ART experienced, with a median age of 6.5 years (IQR, 5.9–9.2 years) and a median baseline CD4+ T-cell percentage of 35% (IQR, 31%–39%). The control group comprised 107 children without HIV infection. The median increase in the CD4+ T-cell percentage was 17 percentage points (IQR, 12–22 percentage points) at week 96 among ART-naive children, and the viral load was<br />We found no evidence of an association between microbial translocation and immune activation in Ugandan human immunodeficiency virus (HIV)–infected children over time during receipt of antiretroviral therapy or in comparison to HIV-uninfected controls. In this setting, other factors may be driving immune activation in both infected and uninfected children.
- Subjects :
- DNA, Bacterial
Male
microbial translocation
pediatrics
HIV Infections
DNA, Ribosomal
immune activation
Major Articles and Brief Reports
children
Humans
Uganda
Child
Inflammation
Africa
HIV
Infant
sequencing
Viral Load
SISTM
CD4 Lymphocyte Count
Bacterial Translocation
Child, Preschool
HIV/AIDS
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 15376613 and 00221899
- Volume :
- 219
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.pmid.dedup....6baa47e4196a586ac58c6e0bb8855c3a