Alzheimer disease: Aβ-independent processes-rethinking preclinical AD

Authors :: Chételat, Gaël
Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine
Université de Caen Normandie (UNICAEN)
Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE)
Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
École pratique des hautes études ( EPHE ) -Université de Caen Normandie ( UNICAEN )
Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Eustache, Francis
Source :: Nature Reviews Neurology, Nature Reviews Neurology, Nature Publishing Group, 2013, 9 (3), pp.123-4. ⟨10.1038/nrneurol.2013.21⟩, Nature Reviews Neurology, Nature Publishing Group, 2013, 9 (3), pp.123-4. 〈10.1038/nrneurol.2013.21〉
Publication Year :: 2013
Publisher :: Nature Pub. Group, 2013.
Abstract: International audience; The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.

Language :: English
ISSN :: 17594758 and 17594766
Database :: OpenAIRE
Journal :: Nature Reviews Neurology, Nature Reviews Neurology, Nature Publishing Group, 2013, 9 (3), pp.123-4. ⟨10.1038/nrneurol.2013.21⟩, Nature Reviews Neurology, Nature Publishing Group, 2013, 9 (3), pp.123-4. 〈10.1038/nrneurol.2013.21〉
Accession number :: edsair.pmid.dedup....70d9093716b3721138e562b3e07069be
Full Text :: https://doi.org/10.1038/nrneurol.2013.21⟩