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The Neurobiological Basis of the Distress Thermometer: A PET Study in Cancer Patients
- Source :
- Stress and health : journal of the International Society for the Investigation of Stress. 31(3)
- Publication Year :
- 2013
-
Abstract
- The objective of this study was to investigate the possible associations between the Distress Thermometer (DT) scores and the brain metabolism of structures involved in stress response. Twenty-one cancer patients were assessed using the DT, Problem Checklist and Hospital Anxiety and Depression Scale (HADS). The psychological measures were correlated with [18 F]PET-FDG brain glucose metabolism. Multiple and linear regression and binary logistic regression were run to analyse data. The DT and HADS scores illustrated that 48% of patients were distressed, 19% were depressed and 48% were anxious. Results showed that some subcortical areas activity, such as part of midbrain and of hypothalamus, was correlated with the DT scores. The Problem Checklist scores correlated with the activity of the same areas and included more regions in the limbic forebrain and brainstem. Compared with the DT and Problem Checklist, HADS-Depression scores showed a more extensive pattern of correlation with brain activity, including limbic and cortical areas. The results highlighted that the DT scores correlated with the activity of brain areas typically involved in stress response. Indeed, hypothalamus metabolism was found to be the best predictor of distressed patients.
- Subjects :
- Adult
Male
Socio-culturale
Fluorodeoxyglucose F18
Neoplasms
Surveys and Questionnaires
cancer
Humans
Aged
Depressive Disorder
Brain
[18 F]FDG PET
Middle Aged
Anxiety Disorders
Distress Thermometer
brain metabolism
depression
Logistic Models
Positron-Emission Tomography
Linear Models
Female
Radiopharmaceuticals
distress thermometer
Stress, Psychological
Subjects
Details
- ISSN :
- 15322998
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Stress and health : journal of the International Society for the Investigation of Stress
- Accession number :
- edsair.pmid.dedup....72c0cb14e0f245a9c6fc2c690422f47c