Angiogenesis in upper tract urothelial carcinoma associated with Balkan endemic nephropathy

Authors :: Velickovic, L. J.
Petrovic, A. R.
Stojnev, S.
Zana Dolicanin
Hattori, T.
Sugihara, H.
Mukaisho, K. -I
Stojanovic, M.
Stefanovic, V.
Source :: Scopus-Elsevier
Publication Year :: 2012
Publisher :: e-Century Publishing Corporation, 2012.
Abstract: Upper tract urothelial carcinoma (UTUC) associated with Balkan endemic nephropathy (BEN) is characterized by a number of aberrations in cell-cycle regulation and apoptosis. The aim of this study was to detect angiogenesis-related marker(s) specific for BEN UTUC, and to examine the influence of HIF 1α upon angiogenesis and apoptosis in UTUC. Present investigation included 110 patients with UTUC, 50 from BEN region and 60 control tumors. Altered expression of VEGFR1 was more often present in control UTUC than in BEN tumors (p

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