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Effects of trapidil after crush injury in peripheral nerve
- Source :
- Acta Medica Okayama. 59(2):37-44
- Publication Year :
- 2005
- Publisher :
- Okayama University Medical School, 2005.
-
Abstract
- In this study, we evaluated the effects of trapidil on crush injury by monitoring nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels and by transmission electron microscopy in the rat sciatic nerve. The sciatic nerve was compressed for 20 sec by using a jewelers forceps. Trapidil treatment groups were administrated a single dose of trapidil (8 mg/kg) intraperitoneally just after the injury. The crush and crush + trapidil treatment groups were evaluated on the 2nd, 7th, 15th, 30th and 45th days of the post-crush period. On the 7th and 15th days, damage in thin and thick myelinated axons, endoneural edema and mitochondrial swelling were less severe in the trapidil group histopathologically. These findings supported the idea that trapidil prevented cell damage and edema at the injury site. Day/group interaction with regard to serum nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels did not show significant changes.
- Subjects :
- Nitrates
electron microscopy
Nerve Crush
Vasodilator Agents
Rats, Inbred Strains
Sciatic Nerve
Rats
Transforming Growth Factor beta2
Microscopy, Electron, Transmission
nervous system
Transforming Growth Factor beta
nitric oxide
Malondialdehyde
trapidil
peripheral nerve
Animals
Edema
Female
Sciatic Neuropathy
Injections, Intraperitoneal
Myelin Sheath
Nitrites
crush injury
Subjects
Details
- Language :
- English
- ISSN :
- 0386300X
- Volume :
- 59
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Acta Medica Okayama
- Accession number :
- edsair.pmid.dedup....7b75fb963f9ed3939cc138a00b9276c1