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Effects of trapidil after crush injury in peripheral nerve

Authors :
Zeliha, Kurtoglu
Ahmet Hakan, Ozturk
Celal, Bagdatoglu
Gurbuz, Polat
Mustafa, Aktekin
Deniz, Uzmansel
Handan, Camdeviren
Ozlen, Bagdatoglu
Mustafa, Sargon
Source :
Acta Medica Okayama. 59(2):37-44
Publication Year :
2005
Publisher :
Okayama University Medical School, 2005.

Abstract

In this study, we evaluated the effects of trapidil on crush injury by monitoring nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels and by transmission electron microscopy in the rat sciatic nerve. The sciatic nerve was compressed for 20 sec by using a jewelers forceps. Trapidil treatment groups were administrated a single dose of trapidil (8 mg/kg) intraperitoneally just after the injury. The crush and crush + trapidil treatment groups were evaluated on the 2nd, 7th, 15th, 30th and 45th days of the post-crush period. On the 7th and 15th days, damage in thin and thick myelinated axons, endoneural edema and mitochondrial swelling were less severe in the trapidil group histopathologically. These findings supported the idea that trapidil prevented cell damage and edema at the injury site. Day/group interaction with regard to serum nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels did not show significant changes.

Details

Language :
English
ISSN :
0386300X
Volume :
59
Issue :
2
Database :
OpenAIRE
Journal :
Acta Medica Okayama
Accession number :
edsair.pmid.dedup....7b75fb963f9ed3939cc138a00b9276c1